Endotoksin bakteri, ke yo rele tou pyrogen, se yon lipopolysaccharide nan miray la selil nan bakteri gram-negatif. Li se yon faktè patojèn ki poze yon menas grav nan sante moun, ak yon ti dòz ka lakòz nan yon pakèt domèn efè byolojik ak pathologie. Kontni endotoksin injectable bakteri ki rive jiska 1ug\/kg ka lakòz reyaksyon negatif, tankou reyaksyon lafyèv, pafwa tanperati kò a ka monte nan plis pase 40 degre, ak nan ka grav, menm koma, tonbe, si se pa sove nan tan, ka menase lavi.
Koulye a, nan pwodiksyon an nan piki, retire elèv la nan endotoksin bakteri souvan itilize aktive metòd adsorption kabòn. Anjeneral, {{0}.
Sepandan, nan pwosesis pwodiksyon an nan injectable hydroxypropyl betacyclodextrin, netwayaj la nan nanofiltrasyon machin, cation résine, filtre katouch ak depo a nan materyèl nan semi-fèmen kondisyon yo se faktè prensipal ki afekte endotoksin bakteri a nan pwodwi an. In order to ensure that the bacterial endotoxin of the product is qualified, we should strictly control each key influencing factor to prevent the resin and cartridge, which are traditionally used for removing impurities, from becoming the source of bacterial endotoxin contamination of the product, and minimize the risk of contamination and cross-contamination in the process of the product according to the requirements of the Code of Practice for the Manufacture of Pharmaceuticals, so as Pou asire ke nou ka kontinyèlman ak stably pwodwi pwodwi a an akò ak estanda kalite itilizatè a.
